<\/a>A rare genetic mutation known as APOE3-R136S, or the \u201cChristchurch mutation,\u201d appears to protect against Alzheimer\u2019s disease by suppressing inflammatory signaling in the brain\u2019s immune cells. Researchers found that this mutation dampens the cGAS-STING pathway, a key innate immune mechanism that is abnormally activated in Alzheimer\u2019s and other neurodegenerative disorders. <\/p>\n","protected":false},"excerpt":{"rendered":"A rare genetic mutation known as APOE3-R136S, or the \u201cChristchurch mutation,\u201d appears to protect against Alzheimer\u2019s disease by suppressing inflammatory signaling in the brain\u2019s immune cells. Researchers found that this mutation dampens the cGAS-STING pathway, a key innate immune mechanism that is abnormally activated in Alzheimer\u2019s and other neurodegenerative disorders.<\/p>\n","protected":false},"author":1,"featured_media":803,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[15],"tags":[],"_links":{"self":[{"href":"http:\/\/sniffmybody.com\/index.php\/wp-json\/wp\/v2\/posts\/801"}],"collection":[{"href":"http:\/\/sniffmybody.com\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/sniffmybody.com\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/sniffmybody.com\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/sniffmybody.com\/index.php\/wp-json\/wp\/v2\/comments?post=801"}],"version-history":[{"count":2,"href":"http:\/\/sniffmybody.com\/index.php\/wp-json\/wp\/v2\/posts\/801\/revisions"}],"predecessor-version":[{"id":804,"href":"http:\/\/sniffmybody.com\/index.php\/wp-json\/wp\/v2\/posts\/801\/revisions\/804"}],"wp:featuredmedia":[{"embeddable":true,"href":"http:\/\/sniffmybody.com\/index.php\/wp-json\/wp\/v2\/media\/803"}],"wp:attachment":[{"href":"http:\/\/sniffmybody.com\/index.php\/wp-json\/wp\/v2\/media?parent=801"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/sniffmybody.com\/index.php\/wp-json\/wp\/v2\/categories?post=801"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/sniffmybody.com\/index.php\/wp-json\/wp\/v2\/tags?post=801"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}