{"id":801,"date":"2025-06-24T13:23:06","date_gmt":"2025-06-24T13:23:06","guid":{"rendered":"http:\/\/sniffmybody.com\/?p=801"},"modified":"2025-06-25T11:26:24","modified_gmt":"2025-06-25T11:26:24","slug":"rare-mutation-shields-brain-from-alzheimers-by-silencing-inflammation","status":"publish","type":"post","link":"http:\/\/sniffmybody.com\/index.php\/2025\/06\/24\/rare-mutation-shields-brain-from-alzheimers-by-silencing-inflammation\/","title":{"rendered":"Rare Mutation Shields Brain from Alzheimer\u2019s by Silencing Inflammation"},"content":{"rendered":"

\"This<\/a>A rare genetic mutation known as APOE3-R136S, or the \u201cChristchurch mutation,\u201d appears to protect against Alzheimer\u2019s disease by suppressing inflammatory signaling in the brain\u2019s immune cells. Researchers found that this mutation dampens the cGAS-STING pathway, a key innate immune mechanism that is abnormally activated in Alzheimer\u2019s and other neurodegenerative disorders. <\/p>\n","protected":false},"excerpt":{"rendered":"

A rare genetic mutation known as APOE3-R136S, or the \u201cChristchurch mutation,\u201d appears to protect against Alzheimer\u2019s disease by suppressing inflammatory signaling in the brain\u2019s immune cells. Researchers found that this mutation dampens the cGAS-STING pathway, a key innate immune mechanism that is abnormally activated in Alzheimer\u2019s and other neurodegenerative disorders.<\/p>\n","protected":false},"author":1,"featured_media":803,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[15],"tags":[],"_links":{"self":[{"href":"http:\/\/sniffmybody.com\/index.php\/wp-json\/wp\/v2\/posts\/801"}],"collection":[{"href":"http:\/\/sniffmybody.com\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/sniffmybody.com\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/sniffmybody.com\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/sniffmybody.com\/index.php\/wp-json\/wp\/v2\/comments?post=801"}],"version-history":[{"count":2,"href":"http:\/\/sniffmybody.com\/index.php\/wp-json\/wp\/v2\/posts\/801\/revisions"}],"predecessor-version":[{"id":804,"href":"http:\/\/sniffmybody.com\/index.php\/wp-json\/wp\/v2\/posts\/801\/revisions\/804"}],"wp:featuredmedia":[{"embeddable":true,"href":"http:\/\/sniffmybody.com\/index.php\/wp-json\/wp\/v2\/media\/803"}],"wp:attachment":[{"href":"http:\/\/sniffmybody.com\/index.php\/wp-json\/wp\/v2\/media?parent=801"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/sniffmybody.com\/index.php\/wp-json\/wp\/v2\/categories?post=801"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/sniffmybody.com\/index.php\/wp-json\/wp\/v2\/tags?post=801"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}