A new study identifies two proteins that interact with a mutant FUS variant linked to familial ALS, offering a potential therapeutic target. Researchers found that inhibiting these proteins in motor neurons derived from human stem cells reduced ALS-related changes. The findings suggest that similar mechanisms may be involved in sporadic ALS, which affects most patients. […]
Memory Cues May Help Reduce Alcohol Consumption
A study suggests that recalling past alcohol experiences before drinking can slow down consumption, indicating a potential strategy to reduce alcohol intake. In the study, women who remembered a previous drinking episode took longer to consume an alcoholic beverage, possibly due to reduced motivation to drink. This approach, along with strong health warnings, may offer […]
COVID’s Spike Protein Enhances Ability to Infect Brain
Researchers have discovered a mutation in the SARS-CoV-2 spike protein that enhances its ability to infect the central nervous system, potentially explaining neurological symptoms and “long COVID.” The mutation was found to allow the virus to better infiltrate the brain, with implications for future treatments targeting COVID-19’s effects on the brain. The findings highlight the […]
Psychosis Cognitive Impairment Linked to Brain Network
New research reveals that cognitive impairments in psychotic disorders, like schizophrenia and bipolar disorder, are connected to brain network organization. This connection is evident even before the first psychotic break in at-risk individuals, offering potential for early diagnosis and intervention. The study highlights a novel brain network-cognition relationship that could lead to targeted treatments for […]
Gene Defect Causes Abnormal Brain Size
Mutations in the gene ZNRF3 can lead to abnormal brain sizes—either too large or too small—causing various neurological symptoms. This gene, known for its role in cancer, is crucial in regulating brain cell production. The study found that specific mutations in the gene disrupt the balance of brain cell development, with potential implications for cancer […]
High-Dose Psilocybin Shows Potential as an Antidepressant Treatment
A meta-analysis suggests that high doses of psilocybin may alleviate depressive symptoms similarly to the SSRI drug escitalopram. While the effect size was small, psilocybin outperformed placebo in clinical trials, though study design flaws could have led to overestimated results. The findings indicate that psilocybin, particularly in high doses, may offer a new avenue for […]
Childhood Inflammation Linked to Later Mental Health Risks
Children with persistent inflammation are at a higher risk of developing mental health disorders like psychosis and depression in early adulthood. A study found that elevated inflammation markers, particularly around age 9, significantly increase the risk of these disorders, as well as cardiometabolic diseases such as insulin resistance. The research suggests that early-life inflammation could […]
Neuroticism Alters How Personality Affects Self-Control
Personality traits like conscientiousness and extraversion are linked to higher self-control, while neuroticism can weaken this effect, especially in specific types of self-control like resisting temptation or initiating proactive behaviors. A study involving 480 military cadets reveals that neuroticism moderates the relationship between other personality traits and self-control, suggesting that the interaction effects differ based […]
Music Therapy Helps in Brain Rehabilitation
Music-based movement therapy, the Ronnie Gardiner Method, shows promise in aiding rehabilitation for stroke and other brain disorders, according to a review from researchers. This rhythmic and engaging approach, which involves coordinated movements and sounds, has been well-received by participants for its enjoyable and social nature. While the method’s potential benefits for stroke recovery are […]
Molecule Discovery Could Revolutionize Chronic Pain Treatment
Researchers have identified a natural molecule, phosphatidic acid, that reduces the sensitivity of touch-sensing ion channels, providing a promising new avenue for managing chronic pain. By increasing levels of this molecule, cells become less sensitive to touch, which was confirmed through tests on sensory neurons and in mice. This discovery could lead to more targeted […]