Rare Mutation Shields Brain from Alzheimer’s by Silencing Inflammation

A rare genetic mutation known as APOE3-R136S, or the “Christchurch mutation,” appears to protect against Alzheimer’s disease by suppressing inflammatory signaling in the brain’s immune cells. Researchers found that this mutation dampens the cGAS-STING pathway, a key innate immune mechanism that is abnormally activated in Alzheimer’s and other neurodegenerative disorders.

How PTSD Disrupts Brain Cell Communication

A new study has examined brains affected by PTSD at the single-cell level, uncovering distinct genetic alterations that may drive the disorder. Researchers focused on the dorsolateral prefrontal cortex, a brain region tied to emotional regulation, analyzing individual cell nuclei to map communication differences across PTSD, major depression, and control brains. They found impaired signaling […]

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